Women Fare Better With Heart Failure

THURSDAY, March 8 (HealthDay News) — Women with heart failure
are less likely to die than men with the condition, according to new
research from Europe.

An analysis of data from 31 studies involving more than 40,000 heart
failure patients found that 25.3 percent of female patients and 25.7
percent of male patients died over three years of follow-up. The death
rate was 135 deaths per 1,000 patient years in women and 137 per 1,000
patient years in men.

However, when the researchers adjusted for age, they found that male
patients had a 31 percent higher risk of death than female patients, and
that being male was an independent risk factor for death.

Compared to men, women with heart failure tend to be older, are more
likely to have a history of hypertension and diabetes, and are less likely
to have heart failure that is caused by reduced blood supply to the heart,
the researchers said.

The study also found that heart failure patients whose left ventricular
ejection fraction is not reduced have a lower death risk than those with
reduced ejection fraction. Reduced ejection fraction is more common in
male heart failure patients than in female patients.

Left ventricular ejection fraction is a measurement used to assess the
function of the left ventricle, which pumps blood into the body’s
circulatory system.

Overall, female heart failure patients were prescribed fewer
recommended treatments for heart failure than men — including
angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor
blockers (ARBs) and beta blockers.

The findings were published March 8 in the European Society of
Cardiology’s European Journal of Heart Failure.

“This study has clearly demonstrated that survival is better for women
with heart failure than for men, irrespective of ejection fraction, age or
other variables,” first author Dr. Manuel Martinez-Selles from the
Gregorio Maranon University Hospital in Madrid, Spain, said in a journal
news release.

There are several possible explanations why women may fare better than
men, he added, including that “the female heart appears to respond to
injury differently from the male heart.”

Women show less “ventricular remodeling,” or structural changes to the
size, shape and function of the heart; greater preservation of right
ventricular function; and seem to be more protected from ventricular
arrhythmias and cell death.

“Some of these advantages could be related to pregnancy and to
sex-specific differences in gene expression,” Martinez-Selles said.

More information

The American Heart Association has more about heart failure.

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