Warfarin Helps Cut Stroke Risk, Researchers Report

TUESDAY, March 27 (HealthDay News) — The anti-clotting drug
warfarin reduces stroke risk in patients with a heart rhythm disorder
called atrial fibrillation, research shows.

In atrial fibrillation — the most common type of irregular
heartbeat — the heart’s upper chambers don’t pump blood properly,
allowing clots to form that can cause a stroke.

Cleveland Clinic researchers led by Dr. Shikhar Agarwal examined data
from more than 32,000 people who took part in eight studies that compared
warfarin (Coumadin) with newer anti-clotting medications.

The investigators found that stroke risk was higher among women, the
elderly, patients who had a previous stroke or mini-stroke (also known as
a transient ischemic attack) and patients who had never taken
anti-clotting drugs called vitamin K antagonists.

The study was released online March 26 in advance of publication in an
upcoming print issue of the Archives of Internal Medicine.

Newer anti-clotting drugs are available and studies have suggested that
some are more effective, safer and easier to use than warfarin, which must
be carefully monitored and can have serious side effects, such as
bleeding. However, these newer drugs are more expensive, so it’s likely
that warfarin will continue to be the most widely used drug for patients
with atrial fibrillation, Agarwal and colleagues said.

A new, promising era in preventing stroke in atrial fibrillation
patients has begun, the authors of an accompanying editorial said.

While newer anti-clotting drugs appear effective, warfarin management
has also advanced and provides safe, effective and inexpensive stroke
prevention treatment for many patients with atrial fibrillation, according
to Dr. Daniel Singer, of Massachusetts General Hospital in Boston, and Dr.
Alan Go, of Kaiser Permanente Northern California in Oakland.

These improvements in warfarin therapy will likely slow the final
transition to the newer drugs, they suggested.

More information

The U.S. National Heart, Lung, and Blood Institute has more about atrial fibrillation.

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