Vitamin D May Not Boost Heart Health in Kidney Patients

TUESDAY, Feb. 14 (HealthDay News) — Vitamin D therapy does not
improve heart health in people with chronic kidney disease, a new study
indicates.

Treatment with vitamin D is primarily recommended for improving bone
health but it has been suggested for other conditions, including
cardiovascular disease. However, there is a lack of convincing data
showing that vitamin D improves cardiovascular health, according to
background information in the study.

Observational studies have reported associations between vitamin D
deficiency and increased risk of cardiovascular events in chronic kidney
disease patients, noted Dr. Ravi Thadhani, of Massachusetts General
Hospital in Boston, and colleagues.

To investigate the effects of vitamin D therapy, the researchers
conducted a clinical trial involving 227 kidney patients with mild to
moderate left ventricular hypertrophy — a heart condition related to
enlargement of the muscle tissue in the wall of the heart’s main pumping
chamber.

The vitamin D compound paricalcitol (Zemplar) was given to 115
patients while another 112 patients received an inactive placebo.

After up to 48 weeks of treatment, neither group showed improvements on
measures of cardiac structure or function. Both groups also had similar
rates of hospitalizations from any cause, but there were fewer
hospitalizations for cardiovascular disease-related events in the vitamin
D group than in the placebo group (one versus eight, respectively).

The study, published in the Feb. 15 issue of the Journal of the
American Medical Association
, was funded by Abbott Laboratories, which
makes paricalcitol.

“At this time, paricalcitol cannot be recommended for patients with
[chronic kidney disease],” Drs. Stefan D. Anker and Stephan von Haehling,
of Charite Campus Virchow-Klinikum in Berlin, Germany, wrote in an
accompanying editorial.

More information

The American Academy of Family Physicians has more about chronic kidney disease.

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