The attack came in the Nad-Ali district in the southern Helmand Province as the US forces were reportedly looking for militants in the volatile region.
After hearing heavy firing, two men went on the roof-top of their home, but were shot dead by the Americans.
The United States launches operations and airstrikes on Afghan residential locations under the excuse of combating militancy. However, the main victims of the US-led offensives are civilians.
The rising death toll for Afghan civilians as a result of NATO and US military operations in the country has increased tensions between President Hamid Karzai and his Western backers.
Despite showing outrage and displeasure over the US-led airstrikes and civilian casualties, the Afghan leader signed a security pact with US President Barack Obama in early May, allowing the American forces to stay one more decade beyond 2014 in the war-ravaged country.
The loss of civilian lives at the hands of US-led foreign forces has dramatically increased anti-American sentiments in Afghanistan, triggering anti-US protests across the war-torn country.
US-led troops have been fighting in Afghanistan since 2001. Their initial offensive removed the Taliban from power, but insecurity continues to rise across the country despite the presence of about 130,000 foreign forces.
MSH/JR/MA
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