The Forgetting Pill Erases Painful Memories Forever

March 3rd, 2012

FAKE NEWS for the Zionist agenda

Photo illustration: Curtis Mann; Photo: Doug Kanter/Getty

By coupling these amnesia cocktails to the memory reconsolidation process, it’s possible to get even more specific. Nader, LeDoux, and a neuroscientist named Jacek Debiec taught rats elaborate sequences of association, so that a series of sounds predicted the arrival of a painful shock to the foot. Nader calls this a “chain of memories”—the sounds lead to fear, and the animals freeze up. “We wanted to know if making you remember that painful event would also lead to the disruption of related memories,” Nader says. “Or could we alter just that one association?” The answer was clear. By injecting a protein synthesis inhibitor before the rats were exposed to only one of the sounds—and therefore before they underwent memory reconsolidation—the rats could be “trained” to forget the fear associated with that particular tone. “Only the first link was gone,” Nader says. The other associations remained perfectly intact. This is a profound result. While scientists have long wondered how to target specific memories in the brain, it turns out to be remarkably easy: All you have to do is ask people to remember them.

This isn’t Eternal Sunshine of the Spotless Mind-style mindwiping. In some ways it’s potentially even more effective and more precise. Because of the compartmentalization of memory in the brain—the storage of different aspects of a memory in different areas—the careful application of PKMzeta synthesis inhibitors and other chemicals that interfere with reconsolidation should allow scientists to selectively delete aspects of a memory. Right now, researchers have to inject their obliviating potions directly into the rodent brain. Future treatments, however, will involve targeted inhibitors, like an advanced version of ZIP, that become active only in particular parts of the cortex and only at the precise time a memory is being recalled. The end result will be a menu of pills capable of erasing different kinds of memories—the scent of a former lover or the awful heartbreak of a failed relationship. These thoughts and feelings can be made to vanish, even as the rest of the memory remains perfectly intact. “Reconsolidation research has shown that we can get very specific about which associations we go after,” LeDoux says. “And that’s a very good thing. Nobody actually wants a totally spotless mind.”

The astonishing power of PKMzeta forces us to redefine human memory. While we typically think of memories as those facts and events from the past that stick in the brain, Sacktor’s research suggests that memory is actually much bigger and stranger than that. In fact, PTSD isn’t the only disease that’s driven by a broken set of memories—other nasty afflictions, including chronic pain, obsessive-compulsive disorder, and drug addiction, are also fueled by memories that can’t be forgotten.

Sacktor is convinced that the first therapeutic use of PKMzeta inhibitors will involve making people forget not an event but physical pain. For reasons that remain mysterious, some sensory nerves never recover from bodily injury; even after a wound heals, the hurt persists. The body remembers. Because these memories are made of the exact same stuff as every other kind of memory, injecting an inhibitor near the spinal cord—where, presumably, the sensation of pain is being stored—and then somehow inducing or focusing on the pain could instantly erase the long-term suffering, as if the nerves themselves were reset. “It’s hard to argue against this form of memory alteration,” Sacktor says. “It might be the only way to treat neuropathic pain.” PTSD is the emotional version of this problem. Instead of the pain coming from the spinal cord, it comes from the amygdala, where a trauma is encoded and just won’t let go. For many reconsolidation researchers, there is little difference among categories of hurt. It doesn’t matter if the tragedy is physical or psychic: The treatment is the same.

There is perhaps no societal plague more expensive than drug addiction. In the US, the overall cost of substance abuse exceeds $600 billion a year. Previous attempts to treat drug addiction with drugs have largely failed; methadone is among the best, and it’s not that good. But addiction is driven by memory—associating the high with a crack pipe, or the buzz of nicotine with the smell of smoke—which means that reconsolidation therapy offers some hope. Studies of morphine-addled rats have found that a few doses of a PKMzeta inhibitor can eliminate their cravings. Nader, meanwhile, has just begun a trial in which cocaine addicts are given propranolol and then shown a drug-related cue, such as a video of people shooting up. Because the blood-pressure medicine dials down their basic emotional response to the world—it reduces symptoms of stress but also inhibits expressions of pleasure—Nader believes it can slowly diminish the desire for illicit substances. “The craving is a learned association,” he says. “We’re hoping to weaken that association over time.”

Being able to control memory doesn’t simply give us admin access to our brains. It gives us the power to shape nearly every aspect of our lives. There’s something terrifying about this. Long ago, humans accepted the uncontrollable nature of memory; we can’t choose what to remember or forget. But now it appears that we’ll soon gain the ability to alter our sense of the past.

The problem with eliminating pain, of course, is that pain is often educational. We learn from our regrets and mistakes; wisdom is not free. If our past becomes a playlist—a collection of tracks we can edit with ease—then how will we resist the temptation to erase the unpleasant ones? Even more troubling, it’s easy to imagine a world where people don’t get to decide the fate of their own memories. “My worst nightmare is that some evil dictator gets ahold of this,” Sacktor says. “There are all sorts of dystopian things one could do with these drugs.” While tyrants have often rewritten history books, modern science might one day allow them to rewrite us, wiping away genocides and atrocities with a cocktail of pills.

Those scenarios aside, the fact is we already tweak our memories—we just do it badly. Reconsolidation constantly alters our recollections, as we rehearse nostalgias and suppress pain. We repeat stories until they’re stale, rewrite history in favor of the winners, and tamp down our sorrows with whiskey. “Once people realize how memory actually works, a lot of these beliefs that memory shouldn’t be changed will seem a little ridiculous,” Nader says. “Anything can change memory. This technology isn’t new. It’s just a better version of an existing biological process.”

It’s a pretty notion—hey, this memory-alteration stuff is totally natural, man—but some ethicists and clinicians dispute whether this kind of therapy is acceptable. Researchers in the field counter that not treating suffering is cruel, regardless of the type of pain involved. We have a duty, they say, to take psychological pain seriously. We can no longer ignore people like Lois. “If you’re in a car accident and you break your leg, everyone agrees we need to give you treatment and painkillers,” Nader says. “But if something terrible happens and your mind breaks, people conclude that treatment is a dangerous idea, at least if it’s effective. But what’s the difference?” Just think of all the poor souls in therapy, trying to talk themselves into a better place. These scientists point out that memory tweaks will one day be used in the same way—except that unlike CISD or Jungian analysis or selective serotonin reuptake inhibitors, these therapies could put permanent recovery just one pill away.

At the moment, of course, such treatments remain entirely hypothetical, an avant-garde limited to the lab. PKMzeta inhibitors can zap rodent memories, but we can’t ask the rats how they feel afterward. Maybe they feel terrible. Maybe they miss their fear. Maybe they miss their morphine. Or maybe all they know is that they miss something. They just can’t remember what.

Contributing editor Jonah Lehrer ([email protected]) is the author of the new book Imagine: How Creativity Works, out in March.

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