Taking Anti-HIV Meds Prior to Exposure May Help Prevent Infection

TUESDAY, May 29 (HealthDay News) — Preventive antiretroviral treatment
appears to be an effective way to help protect high-risk people against
HIV infection, a new study suggests.

HIV, the virus that causes AIDS, can be transmitted through unprotected
sex and contaminated needles.

Immediate treatment after HIV exposure can be successful in preventing
HIV infection, previous research has found. More recently, several large
randomized, controlled trials — the gold standard of medical research, in
which people are randomly assigned to treatment or no treatment — have
shown that giving antiretroviral drugs before people are exposed
may also prevent infection.

For the new report, published May 28 in the CMAJ (Canadian Medical
Association Journal)
, researchers reviewed studies published between
January 1990 and April 2012 and found that preventive antiretroviral
treatment could reduce the risk of HIV infection in high-risk groups such
as gay men, intravenous drug users, and women in areas with high rates of
HIV.

For example, one recent study that included 900 women from a region
with a high rate of HIV found that applying a topical vaginal microbicide
12 hours before and after sex led to a 39 percent reduction in HIV
infection rates.

“All pre-exposure prophylaxis [prevention] interventions should be
considered one part of a more comprehensive plan for preventing the spread
of HIV infection, including standard counseling on safer sexual practices
and condom use, testing for and treating other sexually transmitted
infections and, in select circumstances, male circumcision and needle
exchange programs,” Dr. Isaac Bogoch of Harvard Medical School and
Massachusetts General Hospital in Boston, and colleagues wrote.

While pre-exposure treatment is promising, there are a number of
unanswered questions, such as which groups would benefit most, and the
possibility of the development of drug resistance, the researchers
noted.

More information

The U.S. Centers for Disease Control and Prevention has more about HIV transmission.

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