Surgery Not Best Option for Early Stage Prostate Cancers: Study

WEDNESDAY, July 18 (HealthDay News) — When a man learns he has
localized prostate cancer, he has to make the difficult choice of surgery,
and its possible side effects, or watchful waiting.

Now, a large, long-term study suggests that surgery to remove the
prostate is no better than careful monitoring: Among men with low-grade,
early-stage cancers, a radical prostatectomy did not reduce the
risk of death from prostate cancer or from any other cause.

“This was a very important and difficult study to do because there are
deeply held beliefs that early detection and treatment are beneficial,”
said study author Dr. Timothy Wilt, a professor of medicine at the
Minneapolis VA Center for Chronic Disease Outcomes Research at the
Minneapolis Veterans Affairs (VA) Health Care System. “We showed with
prostate cancer there are small benefits to radical prostatectomy and the
potential for harm.”

Wilt said the results support the recommendations of the U.S.
Preventive Services Task Force and should be reassuring for both patients
and doctors: “Observation can leave patients with a good option, and is a
good treatment choice,” he said.

The findings were published July 19 in the New England Journal of
Medicine
.

In the study, the researchers randomly assigned 731 men with localized
prostate cancer to either have surgery (radical prostatectomy) or
observation. The men joined the study between 1994 and 2002, and were
followed through January 2010. The average age of the men when the study
began was 67 and their mean prostate-specific antigen (PSA) value was 7.8
nanograms per milliliter. All of the participants had negative results on
bone scans — evidence that they didn’t have metastatic (or spreading)
disease.

The researchers assessed problems associated with radical prostatectomy
30 days after surgery and noted issues of urinary incontinence, erectile
dysfunction and bowel dysfunction after two years, as reported by the
patients.

The investigators noted that the data was gathered in the early era of
PSA testing. Current practice — repeated PSA testing using a lower
threshold for biopsy, doing more biopsies more frequently and
systematically upgrading tumors to increase the detection of “indolent”
cancers — increases the likelihood of overdiagnosis and treatment, Wilt
explained.

According to the U.S. National Cancer Institute, there will be about
241,740 new cases of prostate cancer in the United States this year.

In May, the U.S. Preventive Services Task Force recommended against
PSA-based screening for prostate cancer. The task force said there is a
very small benefit to the test and significant harms.

But other expert groups, most recently the American Society of
Clinical Oncology, continue to recommend the tests, at least for those
with a life expectancy of 10 years or more.

Dr. Durado Brooks, director of prostate and colorectal cancers at the
American Cancer Society, said the latest study will be helpful to those
facing a diagnosis of cancer and for the doctors who treat them.

Yet, when faced with a diagnosis of prostate cancer, the vast majority
of men choose to do something very quickly, Brooks noted.

“This is partly because we haven’t had any good long-term studies, but
it’s difficult to get past the fear of the word ‘cancer,'” he explained.
“The study shows the value in taking a step back and looking harder at
watchful waiting or active surveillance.”

More information

To learn more about prostate cancer, go to the U.S. National Cancer Institute.

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