Study Produces Mixed Results on Alzheimer’s Drugs

WEDNESDAY, March 7 (HealthDay News) — A new study offers up
mixed results about two medications used to treat the symptoms of the
memory-robbing disease known as Alzheimer’s.

While patients didn’t get a major mental boost when doctors added the
drug Namenda to their regimen when they were already taking Aricept, they
did find that continuing Aricept — a commonly prescribed drug for
Alzheimer’s in the United States — seemed to help.

The results, which appear in the March 8 issue of the New England
Journal of Medicine
, may seem a bit murky, especially because it’s
difficult to measure the effects of the drugs on day-to-day living.
However, study author Dr. Robert Howard, a professor of old age psychiatry
and psychopathology at the Institute of Psychiatry at King’s College
London, said both drugs are worth taking, possibly even together.

“While these drugs will not stop or slow down the tragic course of
Alzheimer’s disease, they can continue to improve symptoms as the disease
becomes more severe,” Howard said. “If you can, try to stay on them. The
benefits are tangible and, if anything, seem to get larger as the illness
progresses.”

While Alzheimer’s disease is incurable, several drugs are available to
treat symptoms such as memory loss in patients with mild to moderate forms
of the illness. It’s not clear, however, what happens as the disease
worsens.

In the new study, British researchers assigned 295 Alzheimer’s patients
with moderate to severe disease to one of four groups. All had been on the
drug Aricept (donepezil). The patients either continued the drug; stopped
the drug; stopped it and started Namenda (memantine); or they continued
taking Aricept and started taking Namenda, too.

The study, which lasted for a year, was funded by the U.K. Medical
Research Council and the U.K. Alzheimer’s Society.

Patients who continued on Aricept had less impairment than those who
didn’t; the improvement was equal to about three to four months of
decline, Howard said. “That’s a noticeable difference for patients,
caregivers and their doctors.”

However, there didn’t seem to be any significant benefit to taking both
drugs. That contradicted a previous study that found there was a benefit,
said Dr. Lon Schneider, a professor of psychiatry, neurology and
gerontology at the University of Southern California Keck School of
Medicine, who wrote a commentary accompanying the study.

Aricept can be a difficult drug to tolerate. About half of those who
take it will quit due to side effects, Schneider explained. Those side
effects include anorexia, weight loss, heart trouble and agitation.

The findings could be interpreted in various ways, Schneider noted.
The study provides evidence to support continuing Aricept, he said, and
suggests that it may not be not necessary to start Namenda.

Schneider said he doubts the research would have a major impact by
decreasing how often the drugs are prescribed. Still, the findings allow
people to understand how much of an effect patients might encounter if
they go off Aricept, he noted.

More information

For more about Alzheimer’s disease, visit the U.S. National Library of
Medicine.

Views: 0

You can skip to the end and leave a response. Pinging is currently not allowed.

Leave a Reply

Powered by WordPress | Designed by: Premium WordPress Themes | Thanks to Themes Gallery, Bromoney and Wordpress Themes