WEDNESDAY, July 18 (HealthDay News) — Researchers say they’ve
identified an indicator, or “biomarker,” in the blood that may help
predict a person’s risk of developing Alzheimer’s disease.
For their study, the investigators tested the blood of 99 women, aged
70 to 79, for levels of a fatty compound called ceramides, which is
associated with inflammation and cell death. The women were then followed
for up to nine years and 27 of them developed dementia, including 18 who
were diagnosed with probable Alzheimer’s disease.
Compared to women with the lowest levels of ceramides, those with the
highest levels were 10 times more likely to develop Alzheimer‘s and those
with middle levels of the biomarker were nearly eight times more likely to
develop the memory-robbing disease, according to the findings published in
the July 18 online issue of the journal Neurology.
“Our study identifies this biomarker as a potential new target for
treating or preventing Alzheimer’s disease,” Michelle Mielke, an
epidemiologist with the Mayo Clinic in Rochester, Minn., said in a news
release from the American Academy of Neurology. She was with Johns Hopkins
University at the time of the research.
Another expert stressed the importance of the study and the need for
further research.
“These findings are important because identifying an accurate biomarker
for early Alzheimer’s that requires little cost and inconvenience to a
patient could help change our focus from treating the disease to
preventing or delaying it,” Valory Pavlik, of the Alzheimer’s Disease and
Memory Disorders Center of Baylor College of Medicine in Houston, wrote in
an accompanying editorial.
“While a larger, more diverse study is needed to confirm these
findings, projections that the global prevalence of Alzheimer’s disease
will double every 20 years for the foreseeable future have certainly
increased the sense of urgency among researchers and health care agencies
to identify more effective screening, prevention and treatment
strategies,” Pavlik noted.
More information
The U.S. National Institute on Aging has more about Alzheimer’s disease.
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