Researchers ID Gene for Neck Disorder

FRIDAY, March 9 (HealthDay News) — The first gene linked to an
often painful neck disorder has been identified by researchers.

Adult-onset primary cervical dystonia, which is characterized by
involuntary twisting of the neck, occurs in about 30 of every 100,000
people, previous research has reported.

In this new study, researchers conducted a genetic analysis of a
patient with the condition, his identical twin whose neck also twisted and
family members, some of whom also had the disorder. The investigators
pinpointed a mutation in the CIZ1 gene, which produces a protein expressed
in certain nerve cells in the brain and appears to be involved in cell
cycle activities.

However, the researchers did not identify the cellular mechanism
associated with cervical dystonia.

The study findings were released online in advance of publication in an
upcoming print issue of the Annals of Neurology.

While the researchers believe that CIZ1 is one genetic cause of the
disorder, it’s likely that other genes linked to cervical dystonia will be
found, according to Dr. Ryan Uitti, a neurologist at the Mayo Clinic in
Jacksonville, Fla.

There are a number of treatments for cervical dystonia. The most common
is botulinum toxin injections, which incapacitate the nerve in the
affected muscle and eliminate chronic pain and muscle
pulling/contraction.

But some people with the condition don’t realize that it is unusual and
that they should seek medical help, Uitti noted.

“They think they slept wrong at some point, or, because the twisting
might straighten out with another maneuver, such as walking backwards,
they might actually [not be taken seriously],” Uitti said in a Mayo Clinic
news release.

More information

We Move has more about cervical dystonia.

Views: 0

You can skip to the end and leave a response. Pinging is currently not allowed.

Leave a Reply

Powered by WordPress | Designed by: Premium WordPress Themes | Thanks to Themes Gallery, Bromoney and Wordpress Themes