Pregnancy Safe for Women With Estrogen-Sensitive Breast Cancer

WEDNESDAY, March 21 (HealthDay News) — Pregnancy is safe for
women with estrogen-receptor-positive breast cancer, according to a new
study.

These types of breast tumors are especially sensitive to levels of
estrogen in the body, and the findings address concerns that pregnancy
could increase circulating estrogen and thereby cause the cancer to
return.

This study’s results suggest that becoming pregnant at any time after
being diagnosed with breast cancer does not increase the risk of
recurrence, even if the pregnancy occurs within two years after cancer
diagnosis, according to the researchers.

In addition, breast-cancer patients who become pregnant appear to
survive longer than those who do not, according to Dr. Hatem Azim Jr., a
medical oncologist at the Jules Bordet Institute in Brussels, Belgium, and
colleagues.

Their study included 333 breast-cancer patients who later became
pregnant and 874 breast-cancer patients who did not. Over an average of
nearly five years of follow-up, breast cancer recurred in 30 percent of
all the women.

Fifty-seven percent of the women in the study had
estrogen-receptor-positive breast cancer. Becoming pregnant made no
difference in the length of time that patients with either
estrogen-receptor-positive or estrogen-receptor-negative breast cancer
survived without their cancer recurring, according to the study, which is
slated for presentation Wednesday at the European Breast Cancer
Conference, in Vienna, Austria.

“We found that patients who became pregnant within two years of
breast-cancer diagnosis appeared to have a better disease-free survival
compared to those who did not become pregnant,” Azim said in a conference
news release.

“However, a clear trend over time was not demonstrated; hence this
finding should be interpreted with caution as it could be confounded by
potential selection bias, and hence pregnancy within two years of
diagnosis should be regarded as safe, and not as protective,” Azim
noted.

A secondary goal of the study was to determine the impact of pregnancy
on overall survival.

“We found that breast-cancer patients who became pregnant also had a
lower risk of death compared to their matched controls, irrespective of
[estrogen receptor] status,” Azim said.

Because this study was presented at a medical meeting, the data and
conclusions should be viewed as preliminary until published in a
peer-reviewed journal.

More information

The American Cancer Society has more about pregnancy and breast cancer.

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