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January 11th, 2012 
FAKE NEWS for the Zionist agenda WEDNESDAY, Jan. 11 (HealthDay News) — A new type of stem cell
treatment for people with type 1 diabetes appears to help re-educate rogue
immune system cells, which allows cells in the pancreas to start producing
insulin again.
The treatment, which combines a patient’s immune system cells with stem
cells from a donor’s cord blood, even worked in people with long-standing
diabetes who were believed to have no insulin-producing ability.
Although the treatment didn’t wean anyone off insulin completely,
average blood sugar levels dropped significantly, which would reduce the
risk of long-term complications.
“Our study brings a new hope for people with type 1 diabetes. If we can
control the autoimmunity, we may reverse the diabetes. We showed that the
islets [cells] can start to work again,” said Dr. Yong Zhao, an assistant
professor in the section of endocrinology, diabetes and metabolism at the
University of Illinois at Chicago.
This treatment could potentially be useful in other autoimmune
diseases, such as lupus and rheumatoid arthritis.
“It’s quite remarkable that this approach, based on the re-education of
immune cells, might work so well. The concept is very intriguing, and the
treatment seems to be so simple and so safe,” said Dr. Luca Inverardi,
deputy director of translational research at the Diabetes Research
Institute in Miami.
But he’s also “reasonably cautious,” he said. “The follow-up is long,
up to 40 weeks, but it’s not long enough to declare victory against
diabetes yet,” said Inverardi.
Also, he noted that the study involved only 15 Chinese people, and that
type 1 diabetes is a bit different in that population. He said he’d like
to see larger studies with a more diverse population, followed for a
longer time.
Results of the study were published online Jan. 9 in the journal BMC
Medicine.
Type 1 diabetes, an autoimmune disease, occurs when the body’s immune
system cells mistakenly attack the insulin-producing (beta) cells in the
pancreas. Because their beta cells don’t produce enough or any insulin,
people with type 1 diabetes have to replace the lost insulin through
injections to survive.
Stopping that autoimmune attack appears to be crucial to any treatment
that hopes to cure or reverse type 1 diabetes.
Zhao’s team developed a completely new approach. They take blood from a
patient and separate out the immune system cells (lymphocytes). They
briefly expose those cells to stem cells from umbilical cord blood from an
unrelated infant and return the lymphocytes alone to the patient’s body.
The researchers have dubbed this “Stem Cell Educator Therapy,” because
while exposed to the stem cells, the lymphocytes seem to relearn how they
should behave.
The study participants, who were 15 to 41 years old, had had type 1
diabetes for an average of nine years. Six had some residual beta cell
function and six did not. Both groups were given stem cell educator
therapy. The other three people served as the control group.
The researchers measured C-peptide, a protein fragment that’s a
byproduct of insulin production, and found that the educator therapy group
had improved levels of C-peptide at 12 weeks. These levels continued to
improve until 24 weeks, and remained stable through the follow-up at 40
weeks. There were no changes in C-peptide in the control group.
The average daily dose of insulin dropped almost 39 percent after 12
weeks for the group with some beta cell function and 25 percent in those
with no beta cell function, suggesting that the group with no beta cell
function now produced insulin.
“That means if you stop the autoimmune reaction, you may see beta cell
regeneration, or there might be other precursor cells in the pancreas. If
these data are confirmed, this is a very provocative and remarkable
finding,” Inverardi said.
The average hemoglobin A1C level dropped 1.06 percent for those with
residual beta cell function and 1.68 percent for those without beta cell
function. A1C levels measure average blood sugar levels over two to three
months, and people with type 1 diabetes are advised to maintain A1C levels
below 7 percent. A drop of 1 percent in A1C levels can reduce the risk of
complications.
This was an initial clinical trial designed to test for safety. Zhao
said that in future trials he hopes that with additional treatments people
might get off insulin altogether.
But, even if that’s not possible, the recovery of some beta cell
function would be welcome news. “In the absence of complete remission,
there are very sizable advantages to having some beta cell function,”
Inverardi noted.
Both experts said the treatment appears safe, with no risk of
rejection. No significant side effects were reported during the trial,
other than some arm soreness where blood was taken and returned.
More information
Learn more about type 1 diabetes from the Nemours Foundation’s KidsHealth Web site.
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