Researchers from the universities of Granada (Spain) and Kvopio (Finland) have confirmed that cranberry extract helps fighting urinary tract infections (UTIs) in breastfed babies under one year of age. Their work has demonstrated that this compound prevents the prescription of antibiotics in the prophylaxis for recurrent urinary tract infections in infants with vesicoureteral reflux (VUR), so preventing the risk of increasing the bacterial antibiotic resistance.

This research, published in Anales de Pediatría (Annals of Pediatrics) magazine, has been funded by the Instituto de Salud Carlos III institute. It has counted with the collaboration of the university’s Department of Analytical Chemistry and the Research and Development of Functional Food Centre (CIDAF, for its initials in Spanish), through professor Antonio Segura Carretero, and that of the University of Kvopio, Finland, through professor Tarja Nurmi.

The research involved the participation of 85 children under one year of age and 107 over that age, all of them affected by a recurrent urinary infection. 75 children were administered cranberry extract, while the other 117 were administered trimethoprim, a bacteriostatic antibiotic derived from trimethoxybenzyl pyrimidine, used almost exclusively to treat urinary infections.

Effective in adults and children

The lead author of this work, professor José Uberos Fernández from the Department of Pediatrics (UGR), notes that, according to analysis done at CIDAF, the composition of cranberry extracts available at the market is heterogeneous, and not all the polyphenolic fractions in them are equally useful.

Given the results, “cranberry extract, which in previous researches had already shown effectiveness in preventing urinary infections in adults, is also effective and safe for breastfed infants with this condition.”

Cranberry extract effects have been, after numerous in-vitro tests, classically linked to the amount of proanthocyanidins present in the extract. “This molecule is quickly metabolized in the intestine, and our researches have demonstrated that the concentration of proanthocyanidins detected in urine is very little,” professor Uberos says.

The researcher from UGR emphasizes: “the in-vivo (that is, in humans) anti-adhesive effect, seems to be due to the proanthocyanidins intermediate metabolites and to other polyphenolic molecules present in cranberry extract. In this regard, some phenolic acids derived from metabolized cranberries seem to have some very interesting anti-adhesive properties, and that’s something my team of researchers is working on.”

Moreover, the researchers intend to clarify if its anti-inflammatory properties (also noted by other authors) can improve nephropathies following pyelonephritis and reflux, present in other patients.

Journal Reference:

  1. V. Fernández-Puentes, J. Uberos, R. Rodríguez-Belmonte, M. Nogueras-Ocaña, E. Blanca-Jover, E. Narbona-López. Efficacy and safety profile of cranberry in infants and children with recurrent urinary tract infection. Anales de Pediatría (English Edition), 2015; 82 (6): 397 DOI: