More Kidney Dialysis Is Better, Research Finds

THURSDAY, Feb. 23 (HealthDay News) — If you’re receiving kidney
dialysis, four new studies suggest that you could benefit from longer or
more frequent dialysis sessions.

The treatments can be done at home or at a dialysis center, but it
appears that more time spent doing dialysis can reduce mortality rates and
improve quality of life, according to the research published online and in
the March issue of the Journal of the American Society of
Nephrology
.

“What all of these studies show is that the more time your kidneys are
getting cleaned, the better off you are,” said Dr. Robert Provenzano,
chairman of the department of nephrology at St. John Providence Health
System in Detroit. Provenzano was not involved in the research.

When someone’s kidneys fail, the only options are dialysis or a kidney
transplant. Because there aren’t enough donor kidneys to give transplants
to everyone who needs one, many people must turn to dialysis. In dialysis,
a machine takes over many of the jobs of the kidneys, such as filtering
excess fluid and waste. In the United States, almost 400,000 people
undergo dialysis every year, according to the U.S. National Institute of
Diabetes and Digestive and Kidney Diseases (NIDDK). In 2008, fewer than
18,000 people received a kidney transplant, according to NIDDK.

But, dialysis isn’t perfect. It may not remove enough fluid, and levels
of important nutrients can get out of balance for people on dialysis,
according to background information in one of the studies. In addition,
people on dialysis have to eat a limited diet.

Provenzano said improving dialysis is a big issue, and one of the
biggest questions has been whether more dialysis is better. And, he said,
“If it’s true that more is better, is it longer individual sessions or
more frequent dialysis that’s most beneficial?”

Previous research has suggested that longer dialysis sessions seem to
provide a benefit without increasing the risks of complications. One past
study found that more frequent dialysis could increase the risk of
problems with the dialysis access area.

Here’s what the current studies found:

  • One study included 1,873 daily home dialysis patients and 9,365 people
    undergoing in-center hemodialysis three times a week. “In general, we saw
    a 13 percent reduction in mortality in the home hemodialysis patients,”
    said study author Eric Weinhandl, an epidemiologist at the Chronic Disease
    Research Group at the Minneapolis Medical Research Foundation. The
    survival benefit of daily home dialysis was seen across different groups
    of people — different sexes, races, weights and more. One area that
    wasn’t improved with more frequent dialysis was the number of people who
    died from infections. That rate was slightly higher for the more frequent
    dialysis group, though Weinhandl said it wasn’t clear why that was the
    case.
  • The second study compared standard hemodialysis, which is usually
    three sessions a week for between 2.5 and 5.5 hours a session, to
    intensive home hemodialysis for almost five sessions a week for more than
    seven hours each session. Almost 340 people received home treatment
    compared to about 1,400 people receiving standard care. People who
    received intensive dialysis at home were 45 percent less likely to die
    than patients receiving conventional dialysis over the nearly two-year
    study period.
  • In the third study, researchers compared the health of 746 patients
    who received hemodialysis treatments at a clinic three nights per week for
    about eight hours each night to 2,062 similar patients who received
    conventional dialysis care. As with the other studies, the researchers saw
    a significant benefit from the longer dialysis sessions. During a two-year
    follow-up period, those on night-time dialysis had a 25 percent reduced
    risk of dying. The night-time group also had benefits such as lower
    weight, blood pressure and blood phosphorous levels. (Dialysis patients
    have difficulty maintaining proper phosphorous levels, putting them at
    risk of serious complications such as heart disease. Diet and medications
    help to control these levels.)
  • The last study reexamined the results of two previous studies. They
    looked at frequent (six times per week) treatments vs. conventional
    dialysis. The researchers concluded that more frequent dialysis treatments
    helped lower patients’ blood phosphorus levels over 12 months. And, more
    frequent dialysis reduced their need for phosphorus-lowering medications,
    and might also allow people on dialysis to ease some of their dietary
    restrictions.

The bottom line, Provenzano said, is to “dialyze the maximum amount of
time you possibly can, based on your lifestyle. Get your family actively
involved in your care and, if you can, keep working. Quality of life is
significantly improved if you keep working. Dialysis is not a reason to
stop working or doing activities. Stay active. You’ll feel better.”

More information

Learn more about hemodialysis from the U.S. National Institute of Diabetes and Digestive and Kidney
Diseases
.

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