No deaths or injuries have been reported so far, but 12 families have been evacuated, according to Guana Juato Informa.
The incident was first called in at 8:00 pm local time. Fire crews are reportedly on site trying to battle the blaze.
It is likely that a short circuit in the electrical system ignited the factory blaze, according to local media reports.
Three rescue workers are said to be suffering from carbon monoxide poisoning.
The fire quickly intensified, as the factory allegedly had 600 liters of gasoline stored inside.
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