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October 31st, 2021 
Awake Goy 
By GreenMedInfo Research Group
These bitter mushrooms act as parasites on birch trees, but they’re revered for their medicinal properties, including immunomodulatory, antiviral and antidiabetes effects
Chaga mushrooms aren’t the most attractive fungi on the block, and they’re not the tastiest either, but when it comes to medicinal value, chaga mushrooms are king. Typically consumed in tea form due to their bitter flavor, chaga (Inonotus obliquus) is a tree parasite that slowly decomposes tree trunks.
Most often found on birch trees, the black-brown fungus typically infects 30- to 50-year-old trees and may grow on their trunks for another 80 years,[i] producing a conk — a growth that resembles rust-colored charcoal. Chaga mushrooms have been valued since ancient times, when Hippocrates used chaga infusions to wash wounds.
During the 12th century, chaga was valued for its anti-inflammatory, antiparasitic and gastrointestinal properties, and was recommended for heart and liver diseases.[ii] Later, chaga became revered for its anticancer and antitumor effects, which are still being explored today, along with potent antibacterial, antioxidant, immune stimulant and antiviral functions.[iii]
Top Four Health Benefits of Chaga Mushrooms
Even if you’re not a fan of mushrooms, you can reap the benefits of this medicinal wonder by adding chaga powder to your tea or coffee, or mixing it into a smoothie. Chaga is also available in extract and supplement form, providing an impressive array of health benefits. At GreenMedInfo.com, we’ve compiled 71 diseases that chaga may influence along with 63 of this mushroom’s pharmacological actions.
1. Boost Your Immune System
Polysaccharides in chaga mushrooms have broad biological activity, including anticancer, anti-inflammatory, antiviral and antioxidant effects, as well as being immunomodulatory.[iv] Chaga mushroom may modulate immune response by helping to regulate the secretion of Th1 and Th2 cytokines in immune cells as well as antibody production.[v]
Chaga’s water-soluble polysaccharide ISP2a, in particular, has been found to enhance the immune response of mice with tumors, while also enhancing white blood cell proliferation and increasing production of tumor necrosis factor,[vi] a powerful anti-inflammatory agent. It’s believed that ISP2a may act as a natural antitumor substance with immunomodulatory activity.[vii]
2. Ward Off Viral Infections
Chaga has powerful antiviral activity and was found to suppress the infectivity of pandemic influenza virus in mice as well as the antiviral drug Tamiflu.[viii] It’s also effective against multiple feline viruses and the human viruses herpes simplex virus 1,[ix] HIV type 1 and hepatitis C.
In one study, at the highest concentration, chaga extract completely stopped, or significantly inhibited, the reproduction of hepatitis C virus, with researchers noting, “The presented studies confirm the antiviral effect of I. obliquus and indicate its potential use in the treatment of diseases associated with viral infections.”[x]
3. Anticancer Effects
It’s due to chaga’s potent immunomodulatory effects that it shows promise as a cancer fighter. Due to its antitumor and immunologic effects, many people with cancer use chaga mushrooms as a complementary therapy, and its extract is known to induce autophagy,[xi] which is your body’s way of clearing out damaged cells and making room for new ones.[xii]
Chaga extracts have been found to inhibit proliferation of, or are cytotoxic to, human gastrointestinal tumor cell lines as well as human breast, lung, colon, myeloid leukemia and cervical cancer cell lines.[xiii]
While decreasing tumor cell proliferation and motility, chaga produces no or low toxicity to normal cells,[xiv] and in a study on mice, continuous intake of chaga extract suppressed cancer progression, reducing tumors by 60% and, in metastatic mice, reducing nodules by 25% compared to the control group.[xv]
In another study, which found extracts of chaga mushroom and bamboo leaf had strong antitumor activity, it was suggested that its anticancer effects may be the result of activation of innate immunity.[xvi]
4. Help for Diabetes
Chaga polysaccharides have notable antidiabetic effects, with animal studies finding they can reduce fasting blood glucose levels, improve glucose tolerance and ameliorate insulin resistance.[xvii] In one study, chaga extract at a dose of 250 milligrams (mg) per kilogram (kg) of body weight in mice had “obvious antidiabetes effects,” while a dose of 500 mg/kg “was the same as that of [diabetes drug] metformin.”[xviii]
Is Chaga Suitable as a Daily Tonic?
There’s some debate over whether chaga mushroom should be used as a daily tonic or reserved for specific health conditions. Anecdotal reports of improved digestion and mental calm have been reported from using chaga and other mushrooms daily,[xix] while some herbalists suggest it’s best used as an adjunct therapy when required.[xx]
There’s also concern that this medicinal treasure could be overharvested, as it only reproduces after the death of the host tree. Harvesting chaga conks prior to this time may threaten its ability to reproduce. In Alaska, a lax limit of 10,000 pounds of chaga and other conks per person per year exists, but it’s reportedly being exploited.[xxi]
At this time, however, The Global Fungal Red List classifies chaga as a fungus of “least concern,” meaning it’s still abundant in many areas with no evidence of decline.[xxii]
*WARNING: Always consult a medical herbalist or your health care practitioner when using both natural and pharmaceutical medicines for any diagnosed condition. This article is for informational purposes only and not intended to be used as medical advice.
References [i] J Tradit Complement Med. 2021 Jul; 11(4): 293-302. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240111/ [ii] J Tradit Complement Med. 2021 Jul; 11(4): 293-302. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240111/ [iii] J Tradit Complement Med. 2021 Jul; 11(4): 293-302. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240111/ [iv] Polymers 2021, 13, 1441 https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwifxpCYnJvzAhXXB80KHX3nATUQFnoECCEQAQ&url=https%3A%2F%2Fwww.mdpi.com%2F2073-4360%2F13%2F9%2F1441%2Fpdf&usg=AOvVaw3ep9PJycOr21JncOMpbcfT [v] J Ethnopharmacol. 2011 Oct 11;137(3):1077-82. doi: 10.1016/j.jep.2011.07.024. Epub 2011 Jul 28. https://pubmed.ncbi.nlm.nih.gov/21820502/ [vi] Carbohydr Polym. 2012 Oct 1;90(2):870-4. doi: 10.1016/j.carbpol.2012.06.013. Epub 2012 Jun 17. https://pubmed.ncbi.nlm.nih.gov/22840014/ [vii] Carbohydr Polym. 2012 Oct 1;90(2):870-4. doi: 10.1016/j.carbpol.2012.06.013. Epub 2012 Jun 17. https://pubmed.ncbi.nlm.nih.gov/22840014/ [viii] Nutrients. 2020 Sep; 12(9): 2573. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551890/ [ix] Nutrients. 2020 Sep; 12(9): 2573. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551890/ [x] J Tradit Complement Med. 2021 Jul; 11(4): 293-302. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240111/ [xi] J Ethnopharmacol. 2021 Mar 30 ;274:114081. Epub 2021 Mar 30. www.greenmedinfo.com/article/chaga-mushroom-extract-induces-autophagy-ampk-mtor-signaling-pathway-breast-ca [xii] Exp Gerontol. 2016 Dec 1;85:41-47. doi: 10.1016/j.exger.2016.09.016. Epub 2016 Sep 22. www.ncbi.nlm.nih.gov/pubmed/27666185 [xiii] J Tradit Complement Med. 2021 Jul; 11(4): 293-302. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240111/ [xiv] Int J Med Mushrooms. 2011;13(2):131-43. doi: 10.1615/intjmedmushr.v13.i2.50. https://pubmed.ncbi.nlm.nih.gov/22135889/ [xv] Heliyon. 2016 May; 2(5): e00111. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946216/ [xvi] Nutrients. 2020 Jul 29 ;12(8). Epub 2020 Jul 29. PMID: 32751371 www.greenmedinfo.com/article/these-findings-suggest-potential-application-meshimamax-cancer-prevention-and- [xvii] Biomed Pharmacother. 2017 Nov;95:1669-1677. doi: 10.1016/j.biopha.2017.09.104. Epub 2017 Oct 6. https://pubmed.ncbi.nlm.nih.gov/28954386/ [xviii] J Ethnopharmacol. 2021 Jun 12 ;273:113963. Epub 2021 Feb 26. PMID: 33640441 www.greenmedinfo.com/article/i-obliquus-extract-ameliorated-insulin-resistance-and-lipid-metabolism-disorde [xix] MindBodyGreen. February 9, 2017 https://www.mindbodygreen.com/0-28615/7-things-that-happened-when-i-drank-mushroom-tonic-for-a-month.html [xx] United Plant Savers. February 14, 2017 https://unitedplantsavers.org/the-two-sides-of-chaga/ [xxi] The Global Fungal Red List Initiative, Inonotus obliquus https://iucn.ekoo.se/iucn/species_view/315905/ [xxii] The Global Fungal Red List Initiative, Inonotus obliquus https://iucn.ekoo.se/iucn/species_view/315905/
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