Immune System Glitch Linked to Greater Risk of Death

MONDAY, June 4 (HealthDay News) — People with a certain flaw in their
immune system are up to four times more likely to die than people who
don’t have this “glitch,” a new study indicates.

Researchers from the Mayo Clinic explained that people whose immune
system produced too much of an antibody molecule known as a free light
chain, are far more likely to die from a serious illness, such as cancer,
diabetes or heart disease.

In conducting the study, the researchers examined blood samples taken
from nearly 16,000 people aged 50 and older. They found those with levels
of free light chains that fell in the top 10 percent had a roughly four
times greater risk of death than those with lower levels of the molecule.
After taking differences in age, gender and kidney function into account,
those with the highest levels of the molecule still had double the risk of
dying.

The study authors explained that high levels of free light chains
indicate a greater response by the immune system to infection,
inflammation or another serious disorder.

Although high levels of free light chains may signal immune system
stimulation, the researchers noted it should not be used as a diagnostic
tool.

“We do not recommend this test as a screening test, because it will
only cause alarm,” study author Dr. Vincent Rajkumar, a Mayo Clinic
hematologist, said in a news release. “We do not know why this marker is
associated with higher rates of death. We do not have a way of turning
things around. Therefore, I would urge caution in using this test until we
figure out what to do about it and what these results mean.”

The study authors concluded that more research is needed to determine
exactly why free light chains are associated with a greater risk of death
and if specific treatment options should be explored.

The study was published in the June issue of Mayo Clinic
Proceedings
.

More information

The U.S. National Institutes of Health provides more information on the immune system and disorders.

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