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February 1st, 2012 
FAKE NEWS for the Zionist agenda TUESDAY, Jan. 31 (HealthDay News) — Older women who take popular
medications to control indigestion and heartburn may put themselves at
higher risk for hip fractures, researchers report.
Long-term use of these drugs, called proton pump inhibitors (PPIs), may
increase that risk by 35 percent to 50 percent for current or former
smokers, the researchers added. Prilosec, Nexium and Prevacid are some
examples of these medications.
“Although PPI use might be strongly indicated in some patients, at
least for short-term use, we believe that clinicians should continue to
carefully monitor the need for long-term use of these medications,
specifically among postmenopausal women with a history of smoking,” said
lead researcher Dr. Hamed Khalili, a clinical and research fellow in
gastroenterology at Massachusetts General Hospital in Boston.
“Our data supports the recent decision by the U.S. Food and Drug
Administration to revise labeling of PPIs to incorporate concerns about a
possible increase in risk of fractures with these drugs,” he said.
The report was published in the Jan. 31 online edition of the
BMJ.
For the study, Khalili’s team collected data on almost 80,000
postmenopausal women. Over the course of eight years, from 2000 to 2008,
almost 900 hip fractures occurred — a 35 percent increased risk for women
using PPIs compared to women who didn’t take the drugs.
In absolute terms, the risk of hip fracture works out to about 2.02
fractures for every 1,000 person years for those taking PPIs, compared
with 1.51 fractures per 1,000 person years. Person years are the number of
years in a study multiplied by the number of people in the study.
The increased risk of fractures among women who smoked was even higher,
reaching 50 percent, they added. The longer a women took a PPI, the more
her risk increased, the researchers noted.
In 2000, 6.7 percent of the women used PPIs regularly; by 2008 that had
jumped to 18.9 percent. This could mean that more fractures will be seen
in years to come, they added.
Women who stopped using PPIs saw their risk of hip fracture return to
normal within two years, Khalili’s group noted.
In calculating the risk of hip fracture, the researchers tried to
account for weight, age, exercise, smoking, calcium in the diet and
supplement use.
Dr. Olveen Carrasquillo, chief of general internal medicine at the
University of Miami Miller School of Medicine, said that, “I have really
been concerned about doctors dispensing too many PPIs and people taking
these for life.”
“A lot of the time, PPIs are used for things that are controlled better
with diet,” he said.
PPIs should be given for a few months and then tapered off,
Carrasquillo said. “The problem is that if you stop them suddenly you get
acid rebound, and patients start having symptoms again, so you need to
taper them off the medication slowly,” he explained.
Carrasquillo noted that smokers are at higher risk of gastric problems
and complications from PPIs. So, quitting smoking is a good start in
controlling these issues, he said.
Often, calcium supplements are used to bolster bone strength, but
because PPIs affect the absorption of calcium, taking calcium supplements
may not be effective, he said. The researchers did take calcium supplement
use into account and the risk remained, he added.
“It looks like, even among women who are smokers, taking calcium
supplements doesn’t seem to make a difference,” he said.
There is a small group of patients whose symptoms will persist and for
these patients one has to balance the risk of fracture with the benefit of
the drug, Carrasquillo said. “But in the vast majority of cases these
patients should not be on PPIs,” he said.
More information
For more on PPIs, visit the U.S. National Library of Medicine.
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