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January 5th, 2012 
FAKE NEWS for the Zionist agenda WEDNESDAY, Jan. 4 (HealthDay News) — Some people with advanced
colorectal cancer are resistant to some types of chemotherapy, and a
mutation in the so-called TFAP2E gene may play a part in that resistance,
German researchers report.
Knowing which patients carry the mutation might help doctors tailor
treatments or develop new targets for therapy, the researchers said.
“In our study, we identified a gene which is frequently altered in
colorectal cancer,” said lead researcher Dr. Matthias P.A. Ebert, an
assistant professor of internal medicine at the University of Magdeburg.
“This genetic alteration is associated with increased resistance to
chemotherapy and radiation in colorectal cancers.”
The findings appear in the Jan. 5 issue of the New England Journal
of Medicine.
For the study, Ebert’s team analyzed how the TFAP2E gene functioned in
colorectal cancer tumors.
Overall, they looked at more than 200 patients undergoing chemotherapy
for advanced colorectal cancer. Among the first group of 74 patients, 38
had a mutation in this gene, the researchers found.
Mutated tumor cells in these and other patients made the cells
resistant to fluorouracil, a widely used type of chemotherapy. However,
the mutation did not make the tumor resistant to irinotecan or
oxaliplatin, two other chemotherapy drugs, the researchers found.
In the rest of the patients after the first group, the researchers
found a similar association between the TFAP2E gene mutation and tumors
not responding to chemotherapy with fluorouracil.
“Chemotherapy and radiation is very helpful in the majority of patients
with colon cancer and rectal cancers, respectively,” Ebert said.
“If our studies are confirmed in prospective trials and by other
groups, alteration of the TFAP2E gene could help identify subgroups of
patients with colorectal cancer that would show good response to
chemotherapy or radiation,” he said.
Dr. Durado Brooks, director of the prostate and colorectal cancer
division at the American Cancer Society, said “this is one more brick in
the wall that is slowly helping us build our knowledge and understanding
of how to attack cancer in new and different ways.”
“If the findings are corroborated by other investigators, it could lead
to testing of tumors to find if those tumors are likely to be resistant to
fluorouracil-based chemotherapy,” Brooks said.
It could also help identify new targets for treatment, he said.
Brooks thinks other gene mutations also affect how well chemotherapy
works. Some genetic testing is done now for this purpose, he said;
however, it’s too soon to tell whether TFAP2E may be added to those
tested, he said.
“This is a long way from moving into clinical practice,” Brooks said.
“We need to know a lot more of how this impacts actual patients; all
this data is based on looking at things under a microscope as opposed to
investigating the impact of treatment in patients, which may turn out to
be a little different,” he said. “It’s not ready to move from the lab
bench to the bedside yet.”
More information
To learn about colon cancer, visit the American Cancer Society.
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