Fish Oil Won’t Save Diabetics’ Hearts, Research Suggests

MONDAY, June 11 (HealthDay News) — People with type 2 diabetes
who take omega-3 fatty acid supplements are neither helping nor harming
their heart, a new study finds.

Omega-3 fatty acids — the type found in fish oil — are hugely popular
because research has linked them to a reduction in heart attacks, strokes
and other cardiovascular problems. However, this study found no such
benefits among people with type 2 diabetes, the researchers say.

“Previous studies had suggested that fish-oil supplements may have a
modest benefit in these outcomes — we did not find that at all,” said
researcher Dr. Hertzel Gerstein, a professor of medicine at McMaster
University in Hamilton, Ontario, Canada.

Perhaps diabetics react differently to these supplements, or their risk
of cardiovascular disease is so severe that a higher dose of the
supplement would be needed to see an effect, Gerstein said.

“If you want to prevent cardiovascular disease, heart attacks and
strokes, going out and buying omega-3 fatty acids is not going to do it,”
he said.

Type 2 diabetes, a condition linked to being overweight and marked by
excess blood sugar, can lead to serious health problems, including heart
disease and stroke, if it’s uncontrolled.

The report was published June 11 online in the New England Journal
of Medicine
to coincide with the planned presentation of the study
findings at a meeting of the American Diabetes Association in
Philadelphia.

For the study, more than 12,500 people with type 2 diabetes or
prediabetes and at high risk of cardiovascular events were randomly
assigned to take a daily, 1-gram omega-3 fatty acid supplement or an
inactive placebo. Over roughly six years, the researchers looked for
deaths from cardiovascular causes.

The investigators found that taking an omega-3 fatty acid supplement
had no effect on deaths from heart attack, stroke, other cardiovascular
causes or any other cause.

The supplement did lower the levels of triglycerides, which may be an
indicator of cardiovascular disease risk. But omega-3 fatty acid
supplements had no effect on other lipids, such as “good” HDL cholesterol
and “bad” LDL cholesterol, the researchers noted.

Dr. Joel Zonszein, professor of clinical medicine at Albert Einstein
College of Medicine and director of the Clinical Diabetes Center at
Montefiore Medical Center in New York City, said few studies have shown
convincingly that treating high triglycerides or low HDL cholesterol
improves cardiovascular outcomes.

“These lipoproteins, while good markers, do not appear to benefit when
treated, particularly when compared with statins,” he said.

“Treating LDL cholesterol, especially in patients with type 2 diabetes,
is critical, and statins are best,” Zonszein said.

Another expert, Dr. Spyros Mezitis, an endocrinologist at Lenox Hill
Hospital in New York City, said patients ask about whether or not they
should take omega-3 supplements to lower cholesterol.

“We tell them that statins are drugs that are proven to lower the bad
cholesterol and are associated with a reduction in cardiovascular risks,”
he said.

There are patients who take fish oil on their own, Mezitis said. “We
tell these patients they can continue taking fish oil, but it doesn’t take
the place of a statin,” he said.

The study was funded by drug maker Sanofi.

More information

For more information on diabetes, visit the American Diabetes
Association
.

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