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February 1st, 2012 
FAKE NEWS for the Zionist agenda TUESDAY, Jan. 31 (HealthDay News) — Two new drugs, taken alone
or potentially together, may boost survival for men with advanced
prostate cancer, studies suggest.
The results were so promising that both trials were stopped early to
make sure all participants could benefit from the drugs.
Men enrolled in both studies had what’s known as “metastatic
castration-resistant prostate cancers” — tumors that had continued to
grow and spread despite standard treatment aimed at lowering testosterone
levels. (The male hormone testosterone is thought to feed prostate
cancer).
The data were presented in San Francisco on Tuesday as part of the
Genitourinary Cancers Symposium, sponsored in part by the American Society
of Clinical Oncology (ASCO).
According to ASCO, more than 241,000 men in the United States will be
diagnosed with prostate cancer in 2012, and 28,000 men will die from the
disease.
Prostate cancer often spreads to the bone, but one of the new drugs,
called radium-223 chloride (Ra-223), improved survival and delayed
cancer-related bone problems in men with advanced, spreading tumors, the
researchers said. The first in a new class of prostate cancer medications,
Ra-223 delivers bursts of radiation to the bone, targeting the tumor.
The study included 922 men with advanced prostate cancer that had
spread to the bone. The men were randomly selected to receive either
Ra-223 plus best supportive care or a placebo along with similar care.
Supportive care was aimed at alleviating the symptoms of the cancer,
including pain.
The new drug seemed to help, boosting survival to an average of 14
months compared with just over 11 months for those on the placebo.
Additionally, the average time to the first bone-break, fracture or need
for radiation or surgery was significantly delayed among men treated with
the new drug compared to their counterparts who received placebo — from
8.4 months without Ra-223 to 13.6 months with it. The treatment also
appeared safe, the research team concluded.
“The U.S. Food and Drug Administration said it will fast track [this
drug], and I don’t think additional data will be required,” study lead
author Dr. Oliver Sartor, professor of cancer research at the Tulane
University School of Medicine in New Orleans, said at a meeting press
briefing. He said the hope is that this drug will be available to patients
in 2012. Ra-223 is being developed by Algeta ASA and Bayer Healthcare. The
study was funded by Algeta ASA.
In a second trial, another experimental medicine, called MDV3100,
appeared to boost survival by close to five months among men with advanced
prostate cancer. This drug works by preventing male sex hormones (such as
testosterone) from binding to receptors on cancer cells (the tumor needs
these hormones to survive and thrive).
In the study, close to 1,200 men received either MDV3100 or an inactive
placebo. Median overall survival was 18.4 months for men treated with the
experimental drug compared with 13.6 months for those receiving
placebo.
The new drug also reduced the risk of death by 37 percent compared to
placebo, the researchers said.
Side effects included fatigue, diarrhea and hot flushes, and were
generally considered mild, lead author Dr. Howard Scher, chief of the
genitourinary oncology service and chair of Urologic Oncology at Memorial
Sloan-Kettering Cancer Center in New York City, said at the press
briefing. This drug is being developed by Medivation and Astellas Pharma.
The study was funded by Medivation.
“This is very impressive and unprecedented,” added Dr. Nicholas
Vogelzang, chair and medical director of the developmental therapeutics
committee of U.S. Oncology, a research network specializing in cancer
clinical trials. He moderated the press conference announcing the new
study results. “This is going to change the way we take care of patients
who we see in the office,” he said.
The real gold may be in combining the two therapies, the experts
theorized. “These drugs are going to be used in sequence and we would
expect the survival to be fairly dramatically pushed forward,” according
to Scher. “There will be a major bump up in the overall survival of this
group of patients in the next two to three years.”
Vogelzang agreed: “The synergistic benefit will have to be
demonstrated, but it is very plausible that combining and sequencing these
agents may add even more value than what we see here.” He was a
co-investigator on the Ra-223 study.
Findings presented at medical meetings are typically considered
preliminary until they have been published in a peer-reviewed journal.
More information
There’s much more on prostate cancer at the American Cancer Society.
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