Arthritic Hip May Be Tougher to Treat Than Knee

FRIDAY, Feb. 17 (HealthDay News) — Knees with osteoarthritis are
in a constant state of self-repair, but arthritic hip joints are not,
researchers say.

The discovery was a surprise, said study author Dr. Virginia Kraus, a
professor of rheumatology and immunology at Duke University Medical Center
in Durham, N.C.

The finding “suggests the knee has capacity for repair we didn’t know
about and the main treatment strategy probably would need to focus on
turning off the breakdown of knee tissue,” she said in a Duke news
release.

Knee and hip osteoarthritis may require different treatment approaches,
Kraus said. If joint breakdown could be halted, the natural repair
response in the knee might be sufficient to stop or reverse the arthritis
process.

“At least with the knee you’ve got an ongoing repair response that we
didn’t appreciate until now,” Kraus said. “If you could capitalize on that
and turn off the degradative (breakdown) processing you might have some
good effects.”

However, stopping the degenerative process in hips with osteoarthritis
may not be enough. The hips would also require a treatment to stimulate
factors to help begin repair.

In their study, Kraus and her colleagues identified an indicator of
hip-joint breakdown, specifically an altered protein called D-COMP. In the
circulation, it signals hip degeneration. In cartilage, it provides
insight into the repair response of joint tissues.

It’s the first such “biomarker” specific to a particular joint site and
it may be possible to develop it into a tool for monitoring hip-joint
breakdown, Kraus said.

The study was published Feb. 10 in the Journal of Biological
Chemistry
.

Osteoarthritis, the most common form of arthritis, typically causes
pain, swelling and restricted motion in the joints.

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin
Diseases has more about osteoarthritis.

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